Toxicité des substances chimiques, Analyse Toxicologique.
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Classification du CIRC des substances cancérogènes
Le CIRC (Centre international de recherche sur le cancer) classe les agents, mélanges et expositions en cinq catégories:
Sommaire
Catégorie 1 : cancérogène pour l’homme.
Les agents cancérogènes certains pour l’homme. Un agent (ou un mélange) peut être ajouté à cette liste lorsque les preuves de sa cancérogénicité pour l’homme sont insuffisantes mais qu’il existe des preuves suffisantes de sa cancérogénicité expérimentale pour les animaux de laboratoire et des indications fortes selon lesquelles l’agent (ou le mélange) agit sur les personnes exposées par un mécanisme cancérogène.
Catégorie 2A : cancérogène probable pour l’homme.
les agents (ou les mélanges) probablement Cancérogènes pour l’homme. Le classement d’un agent dans cette catégorie est préconisé lorsqu’il existe des indices concordants de sa cancérogénicité pour l’homme et des preuves suffisantes de cancérogénicité expérimentale chez les animaux de laboratoire.
Catégorie 2B : cancérogène possible pour l’homme.
La liste des cancérogènes du groupe 2B du CIRC répertorie toutes les substances, mélanges et circonstances d’exposition déjà évaluées et classées dans le Groupe 2B, celui des cancérogènes possibles pour l’homme, par le Centre international de recherche sur le cancer.
Catégorie 3 : inclassable quant à sa cancérogénicité pour l’homme.
Cette liste énumère toutes les substances, mélanges et circonstances d’exposition évaluées à ce jour et classées dans le Groupe 3 (inclassables quant à leur cancérogénicité pour l’Homme) du CIRC.
Catégorie 4 : probablement non cancérogène pour l’homme.
Une seule substance, le caprolactame, a été classée dans cette catégorie après évaluation de sa cancérogénicité par le CIRC.
Le caprolactame ou plus précisément l’ε-caprolactame est un lactame comprenant sept atomes dans son cycle. Il sert demonomère dans la synthèse du nylon-6.
Structure du Caprolactame
AGENTS CLASSÉS PAR LES MONOGRAPHIES DU CIRC [1]Site web du CIRC, consulté le 10/02/2016.
Group 1
L’agent est cancérogène pour l’Homme
118 agents
Group 2A
L’agent est probablement cancérogène pour l’Homme
75
Group 2B
L’agent est peut-être cancérogène pour l’Homme
288
Group 3
L’agent est inclassable quant à sa cancérogénicité pour l’Homme
503
Group 4
L’agent n’est probablement pas cancérogène pour l’Homme
1
CAS N°
Agent
Groupe
Volume
Année
Informations supplémentaires
50-00-0
Formaldehyde
1
Sup 7, 62, 88, 100F
2012
50-06-6
Phenobarbital
2B
Sup 7, 79
2001
50-07-7
Mitomycin C
2B
10, Sup 7
1987
50-18-0
6055-19-2
Cyclophosphamide
1
26, Sup 7, 100A
2012
50-29-3
DDT (4,4′-Dichlorodiphenyltrichloroethane)
2A
Sup 7, 53, 113
In prep.
50-32-8
Benzo[a]pyrene
1
Sup 7, 92, 100F
2012
NB: Overall evaluation upgraded to Group 1 based on mechanistic and other relevant data
50-33-9
Phenylbutazone
3
13, Sup 7
1987
50-41-9
Clomiphene citrate
3
21, Sup 7
1987
50-44-2
6-Mercaptopurine
3
26, Sup 7
1987
50-55-5
Reserpine
3
24, Sup 7
1987
50-76-0
Actinomycin D
3
10, Sup 7
1987
51-02-5
Pronetalol hydrochloride
3
13, Sup 7
1987
51-03-6
Piperonyl butoxide
3
30, Sup 7
1987
51-18-3
2,4,6-Tris(1-aziridinyl)-s-triazine
3
9, Sup 7
1987
51-21-8
5-Fluorouracil
3
26, Sup 7
1987
51-52-5
Propylthiouracil
2B
Sup 7, 79
2001
51-75-2
Nitrogen mustard
2A
9, Sup 7
1987
51-79-6
Ethyl carbamate (Urethane)
2A
7, Sup 7, 96
2010
52-01-7
Spironolactone
3
Sup 7, 79
2001
52-24-4
Thiotepa
1
Sup 7, 50, 100A
2012
52-46-0
Apholate
3
9, Sup 7
1987
52-68-6
Trichlorfon
3
30, Sup 7
1987
53-03-2
Prednisone
3
26, Sup 7
1987
53-70-3
Dibenz[a,h]anthracene
2A
Sup 7, 92
2010
NB: Overall evaluation upgraded to Group 2A with supporting evidence from other relevant data
54-05-7
Chloroquine
3
13, Sup 7
1987
54-31-9
Furosemide (Frusemide)
3
50
1990
54-85-3
Isonicotinic acid hydrazide (Isoniazid)
3
4, Sup 7
1987
55-18-5
N-Nitrosodiethylamine
2A
17, Sup 7
1987
NB: Overall evaluation upgraded to Group 2A with supporting evidence from other relevant data
55-98-1
1,4-Butanediol dimethanesulfonate (see Busulfan)
55-98-1
Busulfan
1
4, Sup 7, 100A
2012
55-98-1
Myleran (see Busulfan)
56-04-2
Methylthiouracil
2B
Sup 7, 79
2001
56-23-5
Carbon tetrachloride
2B
20, Sup 7, 71
1999
56-25-7
Cantharidin
3
10, Sup 7
1987
56-38-2
Parathion
2B
30, Sup 7, 112
In prep.
56-53-1
Diethylstilbestrol
1
21, Sup 7, 100A
2012
56-55-3
Benz[a]anthracene
2B
92, Sup 7
2010
56-75-7
Chloramphenicol
2A
Sup 7, 50
1990
NB: Overall evaluation upgraded to Group 2A with supporting evidence from other relevant data
57-06-7
Allyl isothiocyanate
3
73, Sup 7
1999
57-14-7
1,1-Dimethylhydrazine
2B
4, Sup 7, 71
1999
57-39-6
Tris(2-methyl-1-aziridinyl)phosphine oxide
3
9, Sup 7
1987
57-41-0
Phenytoin
2B
Sup 7, 66
1996
57-57-8
beta-Propiolactone
2B
4, Sup 7, 71
1999
57-68-1
Sulfamethazine
3
79
2001
NB: Overall evaluation downgraded to Group 3 with supporting evidence from other relevant data
57-74-9
Chlordane
2B
Sup 7, 53, 79
2001
57-88-5
Cholesterol
3
31, Sup 7
1987
58-08-2
Caffeine
3
51
1991
58-14-0
Pyrimethamine
3
13, Sup 7
1987
58-55-9
Theophylline
3
51
1991
58-89-9
Lindane (see also Hexachlorocyclohexanes)
1
113
In prep.
58-93-5
Hydrochlorothiazide
2B
50, 108
in prep
59-05-2
Methotrexate
3
26, Sup 7
1987
59-87-0
Nitrofural (Nitrofurazone)
3
50
1990
59-89-2
N-Nitrosomorpholine
2B
17, Sup 7
1987
60-09-3
para-Aminoazobenzene
2B
8, Sup 7
1987
60-11-7
para-Dimethylaminoazobenzene
2B
8, Sup 7
1987
60-35-5
Acetamide
2B
7, Sup 7, 71
1999
60-56-0
Methimazole
3
79
2001
60-57-1
Dieldrin
3
5, Sup 7
1987
61-57-4
Niridazole
2B
13, Sup 7
1987
61-82-5
Amitrole
3
79, Sup 7
2001
NB: Overall evaluation downgraded to Group 3 with supporting evidence from other relevant data
62-44-2
Phenacetin
1
24, Sup 7, 100A
2012
NB: Overall evaluation upgraded to Group 1 with supporting evidence from other relevant data
NB: Overall evaluation upgraded to Group 2A with supporting evidence from other relevant data
63-25-2
Carbaryl
3
12, Sup 7
1987
63-92-3
Phenoxybenzamine hydrochloride
2B
24, Sup 7
1987
64-17-5
Ethanol in alcoholic beverages
1
96, 100E
2012
64-67-5
Diethyl sulfate
2A
54, 71
1999
NB: Overall evaluation upgraded to Group 2A with supporting evidence from other relevant data
66-27-3
Methyl methanesulfonate
2A
7, Sup 7, 71
1999
NB: Overall evaluation upgraded to Group 2A with supporting evidence from other relevant data
66-75-1
Uracil mustard
2B
9, Sup 7
1987
67-20-9
Nitrofurantoin
3
50
1990
67-45-8
Furazolidone
3
31, Sup 7
1987
67-63-0
Isopropyl alcohol
3
15, Sup 7, 71
1999
67-66-3
Chloroform
2B
Sup 7, 73
1999
67-72-1
Hexachloroethane
2B
73
1999
68-12-2
Dimethylformamide
3
47, 71
1999
68-76-8
Tris(aziridinyl)-para-benzoquinone (Triaziquone)
3
9, Sup 7
1987
69-53-4
Ampicillin
3
50
1990
70-25-7
N-Methyl-N´-nitro-N-nitrosoguanidine (MNNG)
2A
4, Sup 7
1987
NB: Overall evaluation upgraded to Group 2A with supporting evidence from other relevant data
70-30-4
Hexachlorophene
3
20, Sup 7
1987
71-43-2
Benzene
1
29, Sup 7. 100F
2012
71-55-6
1,1,1-Trichloroethane
3
20, Sup 7, 71
1999
71-58-9
Medroxyprogesterone acetate
2B
21, Sup 7
1987
72-20-8
Endrin
3
5, Sup 7
1987
72-43-5
Methoxychlor
3
20, Sup 7
1987
72-57-1
Trypan blue
2B
8, Sup 7
1987
74-83-9
Methyl bromide
3
41, Sup 7, 71
1999
74-85-1
Ethylene
3
Sup 7, 60
1994
74-87-3
Methyl chloride
3
41, Sup 7, 71
1999
74-88-4
Methyl iodide
3
41, Sup 7, 71
1999
74-96-4
Bromoethane
3
52, 71
1999
75-00-3
Chloroethane
3
52, 71
1999
75-01-4
Vinyl chloride
1
Sup 7, 97, 100F
2012
75-02-5
Vinyl fluoride
2A
Sup 7, 63, 97
2008
NB: (1) Overall evaluation upgraded to Group 2A based on mechanistic and other relevant data; (2) For practical purposes, vinyl fluoride should be considered to act similarly to the human carcinogen vinyl chloride
75-07-0
Acetaldehyde
2B
36, Sup 7, 71
1999
75-07-0
Acetaldehyde associated with consumption of alcoholic beverages
1
100E
2012
75-09-2
Dichloromethane (Methylene chloride)
2A
Sup 7, 71, 110
In prep.
75-21-8
Ethylene oxide
1
Sup 7, 60, 97, 100F
2012
NB: Overall evaluation upgraded to Group 1 based on mechanistic and other relevant data
75-25-2
Bromoform
3
52, 71
1999
75-27-4
Bromodichloromethane
2B
52, 71
1999
75-35-4
Vinylidene chloride
3
39, Sup 7, 71
1999
75-38-7
Vinylidene fluoride
3
39, Sup 7, 71
1999
75-45-6
Chlorodifluoromethane
3
41, Sup 7, 71
1999
75-52-5
Nitromethane
2B
77
2000
75-55-8
2-Methylaziridine (Propyleneimine)
2B
9, Sup 7, 71
1999
75-56-9
Propylene oxide
2B
Sup 7, 60
1994
75-60-5
Dimethylarsinic acid
2B
100C
2012
75-87-6
Chloral
2A
63, 84, 106
2014
75-88-7
2-Chloro-1,1,1-trifluoroethane
3
41, Sup 7, 71
1999
76-01-7
Pentachloroethane
3
41, Sup 7, 71
1999
76-03-9
Trichloroacetic acid
2B
63, 84, 106
2014
76-44-8
Heptachlor
2B
Sup 7, 53, 79
2001
77-09-8
Phenolphthalein
2B
76
2000
77-78-1
Dimethyl sulfate
2A
4, Sup 7, 71
1999
NB: Overall evaluation upgraded to Group 2A with supporting evidence from other relevant data
78-79-5
Isoprene
2B
60, 71
1999
78-87-5
1,2-Dichloropropane
1
41, Sup 7, 71, 110
In prep.
78-98-8
Methylglyoxal
3
51
1991
79-00-5
1,1,2-Trichloroethane
3
52, 71
1999
79-01-6
Trichloroethylene
1
Sup 7, 63, 106
2014
79-06-1
Acrylamide
2A
60, Sup 7
1994
NB: Overall evaluation upgraded to Group 2A with supporting evidence from other relevant data
79-10-7
Acrylic acid
3
19, Sup 7, 71
1999
79-34-5
1,1,2,2-Tetrachloroethane
2B
20, Sup 7, 71, 106
2014
79-43-6
Dichloroacetic acid
2B
63, 84, 106
2014
79-44-7
Dimethylcarbamoyl chloride
2A
12, Sup 7, 71
1999
NB: Overall evaluation upgraded to Group 2A with supporting evidence from other relevant data
79-46-9
2-Nitropropane
2B
29, Sup 7, 71
1999
80-08-0
Dapsone
3
24, Sup 7
1987
80-62-6
Methyl methacrylate
3
Sup 7, 60
1994
81-07-2
Saccharin and its salts
3
Sup 7, 73
1999
NB: Overall evaluation downgraded to Group 3 with supporting evidence from other relevant data
81-15-2
Musk xylene
3
65
1996
81-49-2
1-Amino-2,4-dibromoanthraquinone
2B
101
2013
81-88-9
Rhodamine B
3
16, Sup 7
1987
82-28-0
1-Amino-2-methylanthraquinone
3
27, Sup 7
1987
82-68-8
Quintozene (Pentachloronitrobenzene)
3
5, Sup 7
1987
83-32-9
Acenaphthene
3
92
2010
83-63-6
Diacetylaminoazotoluene
3
8, Sup 7
1987
83-66-9
Musk ambrette
3
65
1996
83-67-0
Theobromine
3
51
1991
84-65-1
Anthraquinone
2B
101
2013
85-01-8
Phenanthrene
3
Sup 7, 92
2010
85-68-7
Butyl benzyl phthalate
3
Sup 7, 73
1999
85-83-6
Scarlet Red
3
8, Sup 7
1987
85-84-7
Yellow AB
3
8, Sup 7
1987
85-86-9
Sudan III
3
8, Sup 7
1987
86-30-6
N-Nitrosodiphenylamine
3
27, Sup 7
1987
86-54-4
Hydralazine
3
24, Sup 7
1987
86-57-7
1-Nitronaphthalene
3
46
1989
86-73-7
Fluorene
3
Sup 7, 92
2010
86-74-8
Carbazole
2B
32, Sup 7, 71, 103
2013
86-88-4
1-Naphthylthiourea (ANTU)
3
30, Sup 7
1987
87-29-6
Cinnamyl anthranilate
3
Sup 7, 77
2000
87-62-7
2,6-Dimethylaniline (2,6-Xylidine)
2B
57
1993
87-68-3
Hexachlorobutadiene
3
73
1999
87-86-5
Pentachlorophenol (see Polychlorophenols)
53, 71
1999
88-05-1
2,4,6-Trimethylaniline
3
27, Sup 7
1987
88-12-0
N-Vinyl-2-pyrrolidone
3
19, Sup 7, 71
1999
88-72-2
2-Nitrotoluene
2A
101
2013
NB: Overall evaluation upgraded to Group 2A with supporting evidence from other relevant data
NB: Overall evaluation upgraded to Group 1 based on mechanistic and other relevant data
101-21-3
Chloropropham
3
12, Sup 7
1987
101-25-7
Dinitrosopentamethylenetetramine
3
11, Sup 7
1987
101-61-1
Michler’s base [4,4´-methylenebis(N,N-dimethyl)benzenamine]
2B
27, Sup 7, 99
2010
101-68-8
4,4′-Methylenediphenyl diisocyanate
3
19, Sup 7, 71
1999
101-77-9
4,4′-Methylenedianiline
2B
39, Sup 7
1987
101-80-4
4,4′-Diaminodiphenyl ether
2B
29, Sup 7
1987
101-90-6
Diglycidyl resorcinol ether
2B
36, Sup 7, 71
1999
102-50-1
meta-Cresidine
3
27, Sup 7
1987
102-71-6
Triethanolamine
3
77
2000
103-03-7
Phenicarbazide
3
12, Sup 7
1987
103-11-7
2-Ethylhexyl acrylate
3
60
1994
103-23-1
Di(2-ethylhexyl) adipate
3
Sup 7, 77
2000
103-33-3
Azobenzene
3
8, Sup 7
1987
103-90-2
Acetaminophen (see Paracetamol)
103-90-2
Paracetamol (Acetaminophen)
3
50, 73
1999
104-94-9
para-Anisidine
3
27, Sup 7
1987
105-11-3
para-Benzoquinone dioxime
3
29, Sup 7, 71
1999
105-55-5
N,N‘-Diethylthiourea
3
79
2001
105-60-2
Caprolactam
4
39, Sup 7, 71
1999
105-74-8
Lauroyl peroxide
3
36, Sup 7, 71
1999
106-46-7
para-Dichlorobenzene
2B
Sup 7, 73
1999
106-47-8
para-Chloroaniline
2B
57
1993
106-50-3
para-Phenylenediamine
3
16, Sup 7
1987
106-51-4
para-Quinone
3
15, Sup 7, 71
1999
106-87-6
4-Vinylcyclohexene diepoxide
2B
Sup 7, 60
1994
106-88-7
1,2-Epoxybutane
2B
47, 71
1999
NB: Overall evaluation upgraded to Group 2B with supporting evidence from other relevant data
106-89-8
Epichlorohydrin
2A
11, Sup 7, 71
1999
NB: Overall evaluation upgraded to Group 2A with supporting evidence from other relevant data
106-93-4
Ethylene dibromide
2A
15, Sup 7, 71
1999
NB: Overall evaluation upgraded to Group 2A with supporting evidence from other relevant data
106-99-0
1,3-Butadiene
1
Sup 7, 54, 71, 97, 100F
2012
107-02-8
Acrolein
3
63, Sup 7
1995
107-05-1
Allyl chloride
3
36, Sup 7, 71
1999
107-06-2
1,2-Dichloroethane
2B
20, Sup 7, 71
1999
107-13-1
Acrylonitrile
2B
71
1999
107-14-2
Chloroacetonitrile
3
52, 71
1999
107-30-2
Chloromethyl methyl ether (see Bis(chloromethyl)ether; chloromethyl methyl ether)
108-05-4
Vinyl acetate
2B
Sup 7, 63
1995
108-10-1
Methyl isobutyl ketone
2B
101
2013
108-30-5
Succinic anhydride
3
15, Sup 7
1987
108-45-2
meta-Phenylenediamine
3
16, Sup 7
1987
108-46-3
Resorcinol
3
15, Sup 7, 71
1999
108-60-1
Bis(2-chloro-1-methylethyl)ether
3
41, Sup 7, 71
1999
108-78-1
Melamine
3
Sup 7, 73
1999
NB: Overall evaluation downgraded to Group 3 with supporting evidence from other relevant data
108-88-3
Toluene
3
47, 71
1999
108-94-1
Cyclohexanone
3
47, 71
1999
108-95-2
Phenol
3
47, 71
1999
110-00-9
Furan
2B
63
1995
110-57-6
trans-1,4-Dichlorobutene
3
15, Sup 7, 71
1999
110-86-1
Pyridine
3
77
2000
110-91-8
Morpholine
3
47, 71
1999
111-42-2
Diethanolamine
2B
77, 101
2013
111-44-4
Bis(2-chloroethyl)ether
3
9, Sup 7, 71
1999
111-76-2
2-Butoxyethanol
3
88
2006
115-02-6
Azaserine
2B
10, Sup 7
1987
115-07-1
Propylene
3
Sup 7, 60
1994
115-28-6
Chlorendic acid
2B
48
1990
115-32-2
Dicofol
3
30, Sup 7
1987
115-96-8
Tris(2-chloroethyl) phosphate
3
48, 71
1999
116-06-3
Aldicarb
3
53
1991
116-14-3
Tetrafluoroethylene
2A
19, Sup 7, 71, 110
In prep.
NB: Overall evaluation upgraded to Group 2A on the basis of sufficient evidence in experimental animals with a striking and atypical pattern of tumours
117-10-2
Dantron (Chrysazin; 1,8-Dihydroxyanthraquinone)
2B
50
1990
117-39-5
Quercetin
3
Sup 7, 73
1999
117-79-3
2-Aminoanthraquinone
3
27, Sup 7
1987
117-81-7
Bis(2-ethylhexyl) phthalate (see Di(2-ethylhexyl) phthalate)
117-81-7
Di(2-ethylhexyl)phthalate
2B
Sup 7, 77, 101
2013
118-74-1
Hexachlorobenzene
2B
Sup 7, 79
2001
118-92-3
Anthranilic acid
3
16, Sup 7
1987
118-96-7
2,4,6-Trinitrotoluene
3
65
1996
119-34-6
4-Amino-2-nitrophenol
3
16, Sup 7
1987
119-61-9
Benzophenone
2B
101
2013
119-90-4
3,3′-Dimethoxybenzidine (ortho-Dianisidine)
2B
4, Sup 7
1987
119-93-7
3,3′-Dimethylbenzidine (ortho-Tolidine)
2B
1, Sup 7
1987
120-12-7
Anthracene
3
92, Sup 7
2010
120-58-1
Isosafrole
3
10, Sup 7
1987
120-71-8
para-Cresidine
2B
27, Sup 7
1987
120-80-9
Catechol
2B
15, Sup 7, 71
1999
121-14-2
2,4-Dinitrotoluene
2B
65
1996
121-66-4
2-Amino-5-nitrothiazole
3
31, Sup 7
1987
121-69-7
N,N-Dimethylaniline
3
57
1993
121-75-5
Malathion
2A
30, Sup 7, 112
In prep.
121-88-0
2-Amino-5-nitrophenol
3
57
1993
122-34-9
Simazine
3
53, 73
1999
122-42-9
Propham
3
12, Sup 7
1987
122-60-1
Phenyl glycidyl ether
2B
47, 71
1999
123-31-9
Hydroquinone
3
15, Sup 7, 71
1999
123-33-1
Maleic hydrazide
3
4, Sup 7
1987
123-91-1
1,4-Dioxane
2B
11, Sup 7, 71
1999
124-48-1
Chlorodibromomethane
3
52, 71
1999
124-58-3
Methylarsonic acid
2B
100C
2012
124-58-3
Monomethylarsonic acid (see Methylarsonic acid)
2B
100C
2012
125-33-7
Primidone
2B
108
In prep.
126-07-8
Griseofulvin
2B
Sup 7, 79
2001
126-72-7
Tris(2,3-dibromopropyl) phosphate
2A
20, Sup 7, 71
1999
NB: Overall evaluation upgraded to Group 2A with supporting evidence from other relevant data
NB: Overall evaluation upgraded to Group 2A with supporting evidence from other relevant data
562-10-7
Doxylamine succinate
3
79
2001
563-41-7
Semicarbazide hydrochloride
3
12, Sup 7
1987
563-47-3
3-Chloro-2-methylpropene
3
63
1995
569-61-9
CI Basic Red 9
2B
57, 99
2010
581-89-5
2-Nitronaphthalene
3
46
1989
592-62-1
Methylazoxymethanol acetate
2B
10, Sup 7
1987
593-60-2
Vinyl bromide
2A
39, Sup 7, 71, 97
2008
NB: (1) Overall evaluation upgraded to Group 2A based on mechanistic and other relevant data; (2) For practical purposes, vinyl bromide should be considered to act similarly to the human carcinogen vinyl chloride
593-70-4
Chlorofluoromethane
3
41, Sup 7, 71
1999
598-55-0
Methyl carbamate
3
12, Sup 7
1987
599-79-1
Sulfasalazine
2B
108
In prep.
602-60-8
9-Nitroanthracene
3
33, Sup 7
1987
602-87-9
5-Nitroacenaphthene
2B
16, Sup 7
1987
604-75-1
Oxazepam
2B
Sup 7, 66
1996
606-20-2
2,6-Dinitrotoluene
2B
65
1996
607-57-8
2-Nitrofluorene
2B
46, 105
2013
609-20-1
2,6-Dichloro-para-phenylenediamine
3
39, Sup 7
1987
613-35-4
N,N‘-Diacetylbenzidine
2B
16, Sup 7
1987
615-05-4
2,4-Diaminoanisole
2B
Sup 7, 79
2001
615-53-2
N-Methyl-N-nitrosourethane
2B
4, Sup 7
1987
618-85-9
3,5-Dinitrotoluene
3
65
1996
621-64-7
N-Nitrosodi-n-propylamine
2B
17, Sup 7
1987
627-12-3
n-Propyl carbamate
3
12, Sup 7
1987
630-20-6
1,1,1,2-Tetrachloroethane
2B
41, Sup 7, 71, 106
2014
631-64-1
Dibromoacetic acid
2B
101
2013
632-99-5
Magenta
2B
Sup 7, 57, 99, 100F
2012
637-07-0
Clofibrate
3
Sup 7, 66
1996
641-48-5
Dihydroaceanthrylene
3
92
2010
680-31-9
Hexamethylphosphoramide
2B
15, Sup 7, 71
1999
684-93-5
N-Methyl-N-nitrosourea
2A
17, Sup 7
1987
NB: Overall evaluation upgraded to Group 2A with supporting evidence from other relevant data
693-98-1
2-Methylimidazole
2B
101
2013
712-68-5
2-Amino-5-(5-nitro-2-furyl)-1,3,4-thiadiazole
2B
7, Sup 7
1987
723-46-6
Sulfamethoxazole
3
Sup 7, 79
2001
759-73-9
N-Ethyl-N-nitrosourea
2A
17, Sup 7
1987
NB: Overall evaluation upgraded to Group 2A with supporting evidence from other relevant data
765-34-4
Glycidaldehyde
2B
11, Sup 7, 71
1999
789-07-1
2-Nitropyrene
3
46
1989
794-93-4
Dihydroxymethylfuratrizine (see also Panfuran S)
3
24, Sup 7
1987
794-93-4
Panfuran S (containing dihydroxymethylfuratrizine)
2B
24, Sup 7
1987
800-24-8
Aziridyl benzoquinone
3
9, Sup 7
1987
804-36-4
Nitrovin
3
31, Sup 7
1987
817-09-4
Trichlormethine (Trimustine hydrochloride)
2B
Sup 7, 50
1990
822-36-6
4-Methylimidazole
2B
101
2013
828-00-2
Dimethoxane
3
15, Sup 7
1987
832-69-9
1-Methylphenanthrene
3
Sup 7, 92
2010
838-88-0
4,4′-Methylene bis(2-methylaniline)
2B
4, Sup 7
1987
842-07-9
Sudan I
3
8, Sup 7
1987
846-50-4
Temazepam
3
66
1996
868-85-9
Dimethyl hydrogen phosphite
3
48, 71
1999
892-21-7
3-Nitrofluoranthene
3
33, Sup 7
1987
915-67-3
Amaranth
3
8, Sup 7
1987
924-16-3
N-Nitrosodi-n-butylamine
2B
17, Sup 7
1987
930-55-2
N-Nitrosopyrrolidine
2B
17, Sup 7
1987
989-38-8
Rhodamine 6G
3
16, Sup 7
1987
1071-83-6
Glyphosate
2A
112
In prep.
1072-52-2
2-(1-Aziridinyl)ethanol
3
9, Sup 7
1987
1116-54-7
N-Nitrosodiethanolamine
2B
17, Sup 7, 77
2000
1120-71-4
1,3-Propane sultone
2A
4, Sup 7, 71, 110
In prep.
NB: Overall evaluation upgraded to Group 2A with supporting evidence from other relevant data
1143-38-0
Dithranol
3
13; Sup 7
1987
1163-19-5
Decabromodiphenyl oxide
3
48, 71
1999
1303-00-0
Gallium arsenide (see Arsenic and inorganic arsenic compounds)
86, 100C
2012
1309-37-1
Ferric oxide
3
1, Sup 7
1987
1309-64-4
Antimony trioxide
2B
47
1989
1314-62-1
Vanadium pentoxide
2B
86
2006
1317-60-8
Haematite
3
1, Sup 7
1987
1318-02-1
Zeolites other than erionite (clinoptilolite, phillipsite,mordenite, non-fibrous Japanese zeolite, synthetic zeolites)
NB: Overall evaluation upgraded to Group 2A with supporting evidence from other relevant data
28434-86-8
3,3′-Dichloro-4,4′-diaminodiphenyl ether
2B
16, Sup 7
1987
29069-24-7
Prednimustine
3
50
1990
29291-35-8
N-Nitrosofolic acid
3
17, Sup 7
1987
29767-20-2
Teniposide
2A
76
2000
NB: Overall evaluation upgraded to Group 2A with supporting evidence from other relevant data
29975-16-4
Estazolam
3
66
1996
30310-80-6
N-Nitrosohydroxyproline
3
17, Sup 7
1987
30516-87-1
Zidovudine (AZT)
2B
76
2000
33229-34-4
HC Blue No. 2
3
57
1993
33419-42-0
Etoposide
1
76, 100A
2012
NB: Overall evaluation upgraded to Group 1 based on mechanistic and other relevant data
33419-42-0
15663-27-1
11056-06-7
Etoposide in combination with cisplatin and bleomycin
1
76, 100A
2012
33543-31-6
2-Methylfluoranthene
3
Sup 7, 92
2010
37319-17-8
Pentosan polysulfate sodium
2B
108
In prep.
37620-20-5
N‘-Nitrosoanabasine (NAB)
3
37, Sup 7, 89
2007
38571-73-2
1,2,3-Tris(chloromethoxy)propane
3
15, Sup 7, 71
1999
40762-15-0
Doxefazepam
3
66
1996
42397-64-8
1,6-Dinitropyrene
2B
46, 105
2013
42397-65-9
1,8-Dinitropyrene
2B
Sup 7, 46, 105
2013
51264-14-3
Amsacrine
2B
76
2000
51481-61-9
Cimetidine
3
50
1990
51630-58-1
Fenvalerate
3
53
1991
52645-53-1
Permethrin
3
53
1991
52918-63-5
Deltamethrin
3
53
1991
53973-98-1
Carrageenan, degraded (Poligeenan)
2B
31, Sup 7
1987
53973-98-1
Poligeenan (see Carrageenan, degraded)
54749-90-5
Chlorozotocin
2A
50
1990
NB: Overall evaluation upgraded to Group 2A with supporting evidence from other relevant data
55557-01-2
N-Nitrosoguvacine
3
Sup 7, 85
2004
55557-02-3
N-Nitrosoguvacoline
3
Sup 7, 85
2004
56894-91-8
1,4-Bis(chloromethoxymethyl)benzene
3
15; Sup 7, 71
1999
57018-52-7
1-tert-Butoxypropan-2-ol
3
88
2006
57117-31-4
2,3,4,7,8-Pentachlorodibenzofuran
1
100F
2012
NB: Overall evaluation upgraded to Group 1 based on mechanistic and other relevant data
57465-28-8
3,4,5,3’,4’-Pentachlorobiphenyl (PCB-126)
1
100F
2012
See Polychlorinated biphenyls, dioxin-like, with a TEF according to WHO
57835-92-4
4-Nitropyrene
2B
46, 105
2013
59277-89-3
Aciclovir
3
76
2000
59536-65-1
Polybrominated biphenyls
2A
41, Sup 7, 107
In prep.
NB: Overall evaluation upgraded to Group 2A with supporting evidence from other relevant data, namely mechanistic similarity with polychlorinated biphenyls classified in Group 1
Fusarium moniliforme, toxins derived from (fumonisin B1, fumonisin B2, and fusarin C)
2B
56
1993
118399-22-7
Nodularins
3
94
2010
122320-73-4
Rosiglitazone
3
108
In prep.
308068-56-6
Carbon nanotubes, multi-walled MWCNT-7
2B
111
In prep.
308068-56-6
Carbon nanotubes, multi-walled, other than MWCNT-7
3
111
In prep.
308068-56-6
Carbon nanotubes, single-walled
3
111
In prep.
308068-56-6
Multi-walled carbon nanotubes MWCNT-7 (see Carbon nanotubes, multi-walled MWCNT-7)
308068-56-6
Multi-walled carbon nanotubes other than MWCNT-7 (see Carbon nanotubes, multi-walled, other than MWCNT-7)
308068-56-6
Single-walled carbon nanotubes (see Carbon nanotubes, single-walled)
308076-74-6
Silicon carbide, fibrous
2B
111
In prep.
409-21-2
Silicon carbide whiskers
2A
111
In prep.
Acheson process, occupational exposure associated with
1
111
In prep.
Acid mists, strong inorganic
1
54, 100F
2012
Acrylic fibres
3
19, Sup 7
1987
Acrylonitrile-butadiene-styrene copolymers
3
19, Sup 7
1987
Alcoholic beverages
1
44, 96, 100E
2012
Aloe vera, whole leaf extract
2B
108
In prep.
Alpha particles (see Radionuclides)
Aluminium production
1
34, Sup 7, 92, 100F
2012
Anaesthetics, volatile
3
11, Sup 7
1987
Androgenic (anabolic) steroids
2A
Sup 7
1987
Areca nut
1
85, 100E
2012
Art glass, glass containers and pressed ware (manufacture of)
2A
58
1993
Auramine production
1
Sup 7, 99, 100F
2012
Benzidine, dyes metabolized to
1
99, 100F
2012
NB: Overall evaluation upgraded to Group 1 based on mechanistic and other relevant data
Beta particles (see Radionuclides)
Betel quid with tobacco
1
Sup 7, 85, 100E
2012
Betel quid without tobacco
1
Sup 7, 85, 100E
2012
Biomass fuel (primarily wood), indoor emissions from household combustion of
2A
95
2010
Bisulfites
3
54
1992
Bitumens, occupational exposure to hard bitumens and their emissions during mastic asphalt work
2B
103
2013
BK polyomavirus (BKV)
2B
104
2013
Boot and shoe manufacture and repair (see Leather dust, Benzene)
25, Sup 7
1987
Bracken fern
2B
40, Sup 7
1987
Calcium carbide production
3
92
2010
Carbon electrode manufacture
2A
92
2010
Carpentry and joinery
2B
25, Sup 7
1987
Chimney sweeping (see Soot)
92
2010
Chlorinated drinking-water
3
52
1991
Chlorinated paraffins of average carbon chain length C12 and average degree of chlorination approximately 60%
2B
48
1990
Chlorophenols (see Polychlorophenols)
Chlorophenoxy herbicides
2B
41, Sup 7
1987
Clonorchis sinensis (infection with)
1
61, 100B
2012
Coal dust
3
68
1997
Coal gasification
1
Sup 7, 92, 100F
2012
Coal, indoor emissions from household combustion of
1
95, 100E
2012
Coffee (urinary bladder)
2B
51
1991
NB: There is some evidence of an inverse relationship between coffee drinking and cancer of the large bowel; coffee drinking could not be classified as to its carcinogenicity to other organs
Coke production
1
Sup 7, 92, 100F
2012
Continuous glass filament (see Glass filament)
Diesel engine exhaust (see Engine exhaust, diesel)
Diesel fuel, marine
2B
45
1989
NB: Overall evaluation upgraded to Group 2B with supporting evidence from other relevant data
Diesel fuels, distillate (light)
3
45
1989
Dry cleaning (occupational exposures in)
2B
63
1995
Dyes metabolized to benzidine (see Benzidine, dyes metabolized to)
NB: The HPV types that have been classified as carcinogenic to humans can differ by an order of magnitude in risk for cervical cancer
Human papillomavirus types 26, 53, 66, 67, 70, 73, 82
2B
100B
2012
Human papillomavirus types 30, 34, 69, 85, 97
2B
100B
2012
NB: Classified by phylogenetic analogy to the HPV genus alpha types classified in Group 1
Human papillomavirus types 5 and 8 (in patients with epidermodysplasia verruciformis)
2B
100B
2012
Human papillomavirus types 6 and 11
3
90, 100B
2012
Human T-cell lymphotropic virus type I
1
67, 100B
2012
Human T-cell lymphotropic virus type II
3
67
1996
Hypochlorite salts
3
52
1991
Insulation glass wool
3
43, 81
2002
Involuntary smoking (see Tobacco smoke, second-hand)
Ionizing radiation (all types)
1
100D
2012
Iron and steel founding (occupational exposure during)
1
34, Sup 7, 100F
2012
Isopropyl alcohol manufacture using strong acids
1
Sup 7, 100F
2012
Isopropyl oils
3
15, Sup 7, 71
1999
JC polyomavirus (JCV)
2B
104
2013
Jet fuel
3
45
1989
Kaposi sarcoma herpesvirus
1
70, 100B
2012
Lead compounds, inorganic
2A
Sup 7, 87
2006
Lead compounds, organic
3
23, Sup 7, 87
2006
NB: Organic lead compounds are metabolized at least in part, to ionic lead both in humans and animals. To the extent that ionic lead, generated from organic lead, is present in the body, it will be expected to exert the toxicities associated with inorganic lead
Leather dust
1
100C
2012
Leather goods manufacture
3
25, Sup 7
1987
Leather tanning and processing
3
25, Sup 7
1987
Lumber and sawmill industries (including logging)
3
25, Sup 7
1987
Madder root (Rubia tinctorum)
3
82
2002
Magenta production
1
Sup 7, 57, 99, 100F
2012
Magnetic fields, extremely low-frequency
2B
80
2002
Magnetic fields, static
3
80
2002
Malaria (caused by infection withPlasmodium falciparum in holoendemic areas)
2A
104
2013
Mate
3
51
1991
Mate, hot
2A
51
1991
Merkel cell polyomavirus (MCV)
2A
104
2013
Metabisulfites
3
54
1992
Methylmercury compounds
2B
58
1993
NB: Evaluated as a group
Microcystis extracts
3
94
2010
Mineral oils, highly-refined
3
33, Sup 7
1987
Mineral oils, untreated or mildly treated
1
33, Sup 7, 100F
2012
Modacrylic fibres
3
19, Sup 7
1987
MOPP and other combined chemotherapy including alkylating agents
1
Sup 7, 100A
2012
Neutron radiation
1
75, 100D
2012
NB: Overall evaluation upgraded to Group 1 with supporting evidence from other relevant data
Nickel compounds
1
Sup 7, 49, 100C
2012
Nickel refining (see Nickel compounds)
11
1976
Nitrate or nitrite (ingested) under conditions that result in endogenous nitrosation
2A
94
2010
Non-arsenical insecticides (occupational exposures in spraying and application of)
2A
53
1991
Oestrogen (see Estrogen)
Opisthorchis felineus (infection with)
3
61
1994
Opisthorchis viverrini (infection with)
1
61, 100B
2012
Oral contraceptives, combined estrogen-progestogen (see Estrogen-progestogen oral contraceptives)
Outdoor air pollution
1
109
In prep.
Outdoor air pollution, particulate matter in
1
109
In prep.
Paint manufacture (occupational exposure in)
3
47
1989
Painter (occupational exposure as a)
1
47, 98, 100F
2012
Particulate matter in outdoor air pollution (see Outdoor air pollution, particulate matter in)
Paving and roofing with coal-tar pitch (see Coal-tar pitch)
35, Sup 7, 92, 100F
2010
Petroleum refining (occupational exposures in)
2A
45
1989
Petroleum solvents
3
47
1989
Phenacetin, analgesic mixtures containing
1
Sup 7, 100A
2012
Pickled vegetables (traditional Asian)
2B
56
1993
Polychlorinated biphenyls, dioxin-like, with a Toxicity Equivalency Factor (TEF) according to WHO (PCBs 77, 81, 105, 114, 118, 123, 126, 156, 157, 167, 169, 189)
1
107
In prep.
NB: Overall evaluation upgraded to Group 1 with strong supporting evidence from other relevant data
Polychlorinated dibenzofurans (see 2,3,4,7,8-Pentachlorodibenzofuran)
3
69
1997
Polychlorinated dibenzo-para-dioxins (other than 2,3,7,8-tetrachlorodibenzo-para-dioxin)
3
69
1997
Polychlorophenols and their sodium salts (mixed exposures)
NB: Specific radionuclides for which there is sufficient evidence in humans are also listed individually as Group 1 agents
Red Meat (consumption of)
2A
114
In prep.
Refractory ceramic fibres
2B
43, 81
2002
Rock (stone) wool
3
43, 81
2002
Rubber manufacturing industry
1
28, Sup 7, 100F
2012
Salted fish, Chinese-style
1
56, 100E
2012
Schistosoma haematobium (infection with)
1
61, 100B
2012
Schistosoma japonicum (infection with)
2B
61
1994
Schistosoma mansoni (infection with)
3
61
1994
Shiftwork that involves circadian disruption
2A
98
2010
Slag wool
3
43, 81
2002
Solar radiation
1
55, 100D
2012
Soot (as found in occupational exposure of chimney sweeps)
1
35, Sup 7, 92, 100F
2012
Special-purpose fibres such as E-glass and ‘475’ glass fibres
2B
81
2002
Sulfites
3
54
1992
Sunlamps and sunbeds (see Ultraviolet-emitting tanning devices)
Surgical implants and other foreign bodies: – Organic polymeric materials (as a group) – Orthopaedic implants of complex composition – Cardiac pacemakers – Silicone breast implants – Implanted foreign bodies of metallic chromium or titanium and of cobalt-based, chromium-based and titanium-based alloys, stainless steel and depleted uranium – Dental materials – Ceramic implants
3
74
1999
Surgical implants and other foreign bodies: – Polymeric implants prepared as thin smooth film (with the exception of poly(glycolic acid)) – Metallic implants prepared as thin smooth films – Implanted foreign bodies of metallic cobalt, metallic nickel and an alloy powder containing 66-67% nickel, 13-16% chromium and 7% iron
2B
74
1999
SV40 polyomavirus
3
104
2013
Tea
3
51
1991
Tetrakis(hydroxymethyl)phosphonium salts
3
48, 71
1999
Textile manufacturing industry (work in)
2B
48
1990
Tobacco smoke, second-hand
1
83, 100E
2012
Tobacco smoking
1
83, 100E
2012
Tobacco, smokeless
1
Sup 7, 89, 100E
2012
Toxins derived from certain Fusariumspecies (see Fusarium)
Ultraviolet radiation (wavelengths 100-400 nm, encompassing UVA, UVB, and UVC)
1
55, 100D
2012
Ultraviolet-emitting tanning devices
1
100D
2012
Urethane (see Ethyl carbamate)
Welding fumes
2B
49
1990
NB: Volume 100D concluded that there is sufficient evidence for ocular melanoma in welders
Wood dust
1
62, 100C
2012
Wood smoke (see Biomass fuel, indoor emissions from household combustion)
[…] Cancers : L’amiante est classée dans le Groupe 1 par le CIRC: […]